Product Description

Description of 10-Hydroxycamptothecin
   Camptothecin is an alkaloid derived from the Chinese tree Camptotheca acuminata Decne. Camptothecin and its derivatives are unique in their ability to inhibit DNA Topoisomerase I, by stabilizing a covalent reaction intermediate termed the cleavable complex which ultimately causes tumor cell death.In clinical settings it is widely believed that camptothecin analogs exhibited remarkable anti-tumor and anti-leukaemia activity. Topoisomerase is a basilic enzyme in the process of DNA replication responsible for the winding / unwinding of the supercoiled DNA composing the chromosomes. If the chromosomes cannot be unwound, transcription of DNA messages cannot occur so that the protein cannot be synthesized, which ultimately causes cell death.Application of camptothecin in clinical settings is limited due to serious side effects and poor water-solubility. At present, some camptothecin analogs—either semi-synthetic or synthetic drugs based on camptothecin—have been applied as cancerous therapy such as topotecan and irinotecan, while others have obtained satisfying curative effects in clinical applications.
10-hydroxycamptothecin is the derivative of camptothecine that is a micro-alkaloid from camptotheca Acuminate (a tree native to mainland China). is a kind of pharmaceutical intermediate, an alkaloid originally isolated from the Camptotheca acuminata, exerted inhibitory effects on DNA topoisomerase (Topo )and has anticancer activity in vitro and in vivo. It can also induce differentiation of leukemia MELCand HL-60cells. The purpose of this study is to investigate the proliferation-inhibiting and differentiation-inducing actions of HCPT on human hepatoma Hep G2 cells.

Functions:
1. 10-Hydroxy camptothecin and its derivatives are unique in their ability to inhibit DNA Topoisomerase I, by stabilizing a covalent reaction intermediate termed the cleavable complex which ultimately causes tumor cell death.
2.In clinical 10-Hydroxy camptothecin is widely believed that camptothecin analogs exhibited remarkable anti-tumour and anti-leukaemia activity. Topoisomerase is a basilic enzyme in the process of DNA replication, it is responsible for the winding / unwinding of the supercoiled DNA composing the chromosomes. If the chromosomes cannot be unwound, transcription of DNA message cannot occur and the protein cannot be synthesized, it ultimately causes cell death.
Pharmacology:anti-cancer, anti-virus, immune inhibition, anti early pregnancy, changes in skin epidermal keratinization process.

Application
1. For laboratory research use only (content determination, identification, pharmacology experiment), shall not be used for medical diagnosis and not for other purposes.
2. In the experiments, used for identification, examination and content determination, impurities and related substances examination standard material.
3.Should as far as possible consistent with products concentrate formulation.