金银花提取物超分子水凝胶的制备和释放行为研究

发布时间:2022-06-08 信息来源:admin 发布人:admin 点击次数:492

金银花提取物超分子水凝胶的制备和释放行为研究
李菀
Preparation of Lonicerae Japonicae Flos extract supramolecular hydrogel and its release behavior in vitro
LI Wan
发布日期：2020-04-10
摘要访问统计PDF预览参考文献
[关键词]
金银花 ; 提取物 ; 超分子水凝胶 ; 缓控释 ; 局部给药 ; 体外释放 ; 酚酸 ; N-芴甲氧羰基-L-苯丙氨酸 ; 凝胶因子 ; 抗菌性能 ; 缓控释特征
[摘要]
目的制备局部给药的金银花提取物超分子水凝胶，并对其进行表征和体外释放行为研究。方法采用40%乙醇提取金银花，以酚酸类成分的含量为定量指标，选取N-芴甲氧羰基-L-苯丙氨酸为凝胶因子，制备金银花提取物超分子水凝胶，采用体外释放实验研究其释放行为。结果加入金银花提取物，不影响超分子水凝胶的形成及其抗菌性能，还有利于提高超分子水凝胶的稳定性。金银花提取物的释放行为与其负载量和释放介质pH值有关，金银花提取物的负载量为0.5 mg/mL时，其累积释放率最大；提取液的累积释放率随释放介质的pH值升高而增大，表现出明显的缓控释特征。结论超分子水凝胶作为金银花提取物的释放载体，具有明显的缓控释作用，为金银花在医药方面的开发和应用提供了新思路。
[Key word]
Lonicerae Japonicae Flos ; extract ; supramolecular hydrogel ; sustained and controlled release ; local delivery ; in vitro release ; phenolic acid ; N-(9-fluorenylmethoxycarbonyl)-L-phenylalanine ; gelator ; antibacterial activity ; sustained and controlled-release feature
[Abstract]
Objective To prepare the Lonicerae Japonicae Flos (LJF) extract supramolecular hydrogel and investigate its properties and release behavior in vitro. Methods The LJF was extracted with 40% ethanol. Taking the content of phenolic acids as the quantitative index, N-(9-fluorenylmethoxycarbonyl)-L-phenylalanine was selected as the gelator to prepare LJF extract supramolecular hydrogels. The release behavior was studied by in vitro release experiment. Results The addition of LJF extract not only did not affect the formation of supramolecular hydrogel, but also improved the stability of supramolecular hydrogel. The release behavior of LJF extract was related to its loading and pH value of release medium. When the drug loading of LJF extract was 0.5 mg/mL, the cumulative release rate was the highest. Moreover, the cumulative release rate increased with the pH value of the release medium, showing obvious controlled release characteristics. Conclusion Supramolecular hydrogels as the release carrier for LJF extract have an obvious sustained and controlled release, which provides a new idea for the development and application of LJF in medicine.